Tinnitus

Public Forum
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I should mention that the slowing of the degradation of acetylcholine can also be achieved by taking Huperzine A: Huperzine A: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

I’ve never tried it myself, but it does the same thing as DMSO with respect to slowing of the degradation of acetylcholine.

“Huperzine A is being investigated as a potential treatment for tinnitus, particularly in cases related to aging and hearing loss (presbycusis). A clinical trial is underway to evaluate its effects on tinnitus suppression, hearing, and cognitive function in older adults with subjective tinnitus and mild cognitive impairment. The theory is that since aging can cause both hearing loss and cognitive decline, and both are linked to cholinergic hypofunction, Huperzine A may be beneficial.”

So, I think we’re onto something with respect to the involvement of acetylcholine and tinnitus.

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A Midwestern Doctor gives us a couple more clues about how to use DMSO (percent) for tinnitus (assuming acetylcholine is the link) and a warning about other acetylcholine esterase inhibitors like Huperzine A:

“However, unlike other acetylcholine esterase inhibitors, at high doses it hasn’t been observed to cause a cholinergic syndrome (which may be because while under 1% DMSO is an acetylcholine esterase inhibitor, over 10% blocks cholinergic transmission, or because it is a competitive rather than irreversible inhibitor, or as the previously cited studies show, because its inhibition is significantly weaker than the pharmaceutical drugs used as acetylcholine esterase inhibitors).”

This doesn’t necessarily mean you need to use a DMSO concentration less than 10%, because what reaches the cochlea, depending on the route of administration, will most likely be less than 10%. I think the takeaway here is that if you use too high of a concentration of DMSO you may actually find the tinnitus gets worse (“over 10% blocks cholinergic transmission”) but getting the dosage right is the trick (“under 1% DMSO is an acetylcholine esterase inhibitor”).

Again, I’m not a medical professional, just someone digging into data and making inference and educated guesses.

What I have a prescription for is the following (and again, this is my prescription, not one for anyone else):

Tinnitus:

-DMSO ear drops- 20% solution in saline or distilled water

2 drops each ear once daily

*** OK to increase the concentration to 40 % after tolerating 20 %*

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jrgerber, this caught my attention re: DMSO. I don’t understand at all what is written here about acetylcholinesterase etc. but wonder if therein lies why some people don’t respond to DMSO. Therein meaning having something to do with acetylcholine or ??? I have applied it topically a lot and not sure there has been much response. This may be beyond your wheelhouse but asking just in case. Thanks either way and thanks for your wonderful input to this forum.

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Sorry if I was jumping into the middle of things too much. I should remember to give the basics. So, the body has a parasympathetic system and a sympathetic system. The parasympathetic system is the “rest and digest” system. The sympathetic is the “fight or flight” system. The two systems must keep one another in balance. Things like spike protein can hurt the “rest and digest” parasympathetic system which means the “fight or flight” gets out of hand without its counterpart “rest and digest” working. This “rest and digest” system is run by acetylcholine. The fight or flight is run by adrenaline. So, you can think of acetylcholine as the opposite of adrenaline or the thing that cancels it out when the body needs to do that. Tinnitus is likely caused by acetylcholine not working properly in the inner ear, in what is called the cochlea. It might sound strange that the “rest and digest” system is part of the cochlea but if you think about calming the sounds of tinnitus down, it might make more sense.

The body has a way to remove acetylcholine… it’s like a drain in a sink and that is called “acetylcholine esterase”. When I see “esterase” in medical literature I think “something that removes something”. What DMSO does is it sort of puts a rag into the drain… it slows down the removal of acetylcholine… which means the sink starts filling up with it… and that helps the cochlea which is starving for more acetylcholine, and that makes it so the tinnitus goes down.

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So much interesting information. Thank you to everyone who replied.

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Ah, topically DMSO has this interesting property of very easily going through the skin. If you combine DMSO with something else, it will bring the something else through the skin. For example, if a person were trying to get drunk through the skin, they might try grain alcohol with DMSO on their skin. I’m not suggesting doing this but trying to give an example. Or with pain, if you have aspirin (or perhaps go with willow bark - where aspirin comes from) and put that with DMSO on the skin, then you get the analgesic effects soaking straight through the skin because of the DMSO. For a herpes outbreak a person might use DMSO and chlorine dioxide (in the correct dosages of course) in combination directly on the skin. Those two are used in combination for a number of things: CHLORINE DIOXIDE TREATMENTS & TESTIMONIALS : Brian Stone : Free Download, Borrow, and Streaming : Internet Archive

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As always, my thanks to you. I have read in Midwestern Doctor that there is a small percentage of people who are not affected by DMSO. Hope I’m not one, but there is a question, at least topically. I have not, however, taken it internally yet. Same with MMS - for some reason a bit hesitant to take it orally but I will do so. . . eventually. The reference you offered on internet archive looks great!

You brought up herpes and this was posted on the earthclinic.com site - taken from a book that is no longer in print but the one who posted it said it had actually prevented further outbreaks. Period.

To prevent genital outbreaks from appearing, apply a thin layer of DMSO cream at prodome to a fairly large area (about 3-5 inches in diameter) at the lower spine near the tailbone, and to all areas of previous outbreaks. Repeat the application 3 to 5 times daily for three consecutive days. Do not rub vigorously into the skin; just apply.

To prevent cold sores from appearing, apply a thin layer of DMSO cream at prodome to the back of the neck 3 times daily for three consecutive days. Also apply DMSO roll-on to areas of previous outbreaks five to six times daily. Carry DMSO roll-on with you and apply frequently during the day, as you would a lip balm. DMSO can also be used for cracked, dry or chapped lips.

To prevent facial outbreaks from appearing, apply DMSO cream to the back of the neck three times daily for three consecutive days. Also apply DMSO cream with aloe vera to all areas of previous outbreak 3 to 5 times daily for three consecutive days. If you don’t have DMSO cream with aloe vera, you can use DMSO cream alone.

For outbreaks inside the mouth, apply DMSO cream to the back of the neck three times daily. Also rinse with dilluted OXygen Force (5 drops OxyForce to 2 ounces of water) three to five times daily. The area normally will clear overnight, but almost always within three days.

Preventing future outbreaks

To prevent future outbreaks, even when clear, follow the three day procuedure once (or twice) a month for three to five months. If you experience outbreaks more than once a month, follow the three-day procedure twice a month. Following the three-day procedure more often is safe but not usually necessary.

When an outbreak is in progress, apply DMSO cream with aloe vera (preferred) or DMSO cream 3 to 5 times daily to the outbreak area until completely clear.

DMSO cream: use on the ganglion areas located on the top and bottom of the spine, and on all previous outbreak areas

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:+1:

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@gratitude - great info - thank you

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:+1::+1:

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The mechanism of action with DMSO I just read about. I picked up an eBook from my library of “Healing with DMSO” by Amandha Dawn Vollmer yesterday.

Page 10:

"Let’s go back to the fact that DMSO can easily move through the membranes of plants and the skin of people and animals. DMSO exchanges sites with bound water molecules. Imagine dancers grabbing hands in an alternating fashion moving through a line. One after the other, they make their way down the line, all the while exchanging handshakes with new partners. This is how DMSO moves through tissue, exchanging hands with water.

In 2017, scientists at the University of Texas ran a study on the hydrogen bonds that form between DMSO and water. The study found that at low concentrations, DMSO forms two hydrogen bounds with water; at medium concentrations it forms only one hydrogen bond with water; at very high concentrations, it ignores water and clumps with other DMSO molecules. These results provide valuable insight on proper dosing for a wide range of health and industry applications. The dosage always matters in medicine, but with DMSO’s unique chemistry, it’s even more important to understand."

So, what this tells me is that the dosage you are using, whether it’s 10%, 20%, 50%, 80%, 99.98%, makes a big difference in how DMSO will act on your skin. What also matters is how hydrated you and your skin is. This may be the key factor for what you are trying to do with DMSO is getting the correct dosage. Sometimes less is more being the moral of the story.

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:clap: Great info!