Has anyone developed thrombocythemia after taking the first 2 doses of the Moderna C19 shots? I would like to connect and share what I have learned and also what others may know. I am previously healthy and was work mandated to take the shots and religious exemption was disallowed. I now have thrombocythemia 4 years later (mild) and tested positive for JAK2V617F, which I strongly believe I acquired from the shots.
I wasn’t familiar so I had to look up ‘thrombocythemia’ and JAK2V617F … .
Correct Understanding:
- The JAK2V617F mutation occurs first, causing a dysregulated JAK-STAT signaling pathway.
- This leads to overproduction of blood cells, including platelets, which results in essential thrombocythemia (ET).
- The mutation predisposes an individual to develop ET, polycythemia vera (PV), or primary myelofibrosis (PMF), depending on other genetic and biological factors.
Key Mechanism:
- Mutation in JAK2 gene (JAK2V617F) →
- Constant activation of JAK-STAT pathway (growth signal always “on”) →
- Increased platelet production by megakaryocytes →
- Essential thrombocythemia (high platelet count) develops
Does Thrombocythemia Cause JAK2V617F?
No, having high platelet counts does not trigger the JAK2V617F mutation. The mutation is a somatic (acquired) genetic change that occurs in a single hematopoietic stem cell, which then expands abnormally.
If the above is correct – then your question is whether the ‘shots’ triggered the JAK2V617F mutation … which then resulted in thrombocythemia . According to ChatGPT – VERS didn’t have too many reports from the mRNA shots … but I’m not so sure VERS is a reliable source. I’d be suspicious of the shots causing this too. ☼ How soon from the shots did you figure out you ET ..??..
I was diagnosed with ET 2 years after getting the Moderna vaccine, and had just had a full lab ran 2 years before that and was fine. I have CALR mutation but I do believe the vaccine had something to do with this.