How to increase lymphocytes

Public Forum
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Any supplements or drugs that are known to increase lymphocytes?

After radiation therapy for cancer my total lymphocytes dropped in half
to about 1, and in 3 years I haven’t been able to increase them.

I take several things that are supposed to increase NK cells, and many things that supposedly "help the immune system:. My B cells are low normal due to an immune deficiency (although my main problem is they make antibodies incorrectly.) If I could get my WBC/lymphocytes to go up, at least I’d have more working immune cells.

Thanks

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https://tuckercarlson.com/tucker-show-patrick-soon Dr. Soon-Shiong had mentioned in this video a couple of things additionally that help NK. IIRC he said sleep and infrared light, but I’d have to watch again to catch all of what he mentioned. I’m a big proponent of IR light benefits and I have a system at home. IR light has an additive effect with methylene blue and that combination is worth researching as well. There have been many experiments over the years that involve both. The 2023 FLCCC talks by Dr. Mobeen Syed (Methylene Blue) and Dr. Paul Marik (Infrared) explains the physics of both (electron transport chain complex IV). Hearing IR reinforced by Dr. Soon caught my attention once again to the amazing range of applications. Skin cancer is another interesting application of combining both that I recently read an article about. Hopefully that gives you some more ammunition to bolster your immune system with!

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It would not be surprising if an unhealthily low number of lymphocytes was at least partly caused by inadequate circulating 25-hydroxyvitamin D.

The immune system can only function properly with 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D, as measured in “vitamin D” blood tests. Most people have less than this, especially in winter and if they have black or brown skin, are elderly and/or have sun avoidant lifestyles.

25-hydroxyvitamin D (calcifediol AKA “calcidiol” is produced, over several days, primarily in the liver by hydroxylating vitamin D3 (cholecalciferol) on the 25th carbon. Neither of these are hormones. These are not signaling molecules. The immune system does not use hormonal signaling.

There is very little vitamin D in food, including in food fortified with vitamin D3 or the less effective vitamin D2. Until the late 1920s, the primary source of vitamin D3 was ultraviolet-B irradiation of the skin, where it breaks a bond, opening up one of the carbon rings of 7-dehydrocholesterol to form a molecule which changes shape of its own accord to become stable vitamin D3. Far from the equator, sufficient UV-B light to do this is only available in the middle of cloud-free summer days, without glass, clothing or sunscreen intervening. However, this UV-B also damages DNA and so raises the risk of skin cancer.

In winter, many people who do not supplement vitamin D3 at all, or who do so in the very small amounts recommended by many doctors (such as 25 micrograms = 1000 IU a day, on average) have 25-hydroxyvitamin D levels below 25 ng/mL (62.5 nmol/L). Some have 5 ng/mL (12.5 nmol/L) or less, even in sunny Israel, See Figure 1 in https://www.medrxiv.org/content/10.1101/2020.09.04.20188268v1.

Consequently, most people cannot be fully healthy without proper vitamin D3 supplementation.

If we had no supplemental vitamin D3, health would be optimised by some level of UV-B skin exposure which trades off the skin cancer risk against the essential benefits of improving immune system function by raising 25-hydroxyvitamin D levels. However, since vitamin D3 (produced by UV-B irradiation of 7-dehydrocholesterol made from wool fat) is so inexpensive and readily available, the best approach is to supplement properly and avoid excessive UV-B exposure.

Please see the research articles cited and discussed at: https://vitamindstopscovid.info/00-evi/.

This includes descriptions of the compounds and recommendations from New Jersey based Professor of Medicine Sunil Wimalawansa on how much vitamin D3 cholecalciferol to supplement, on average, per day, to attain at least 50 ng/mL circulating 25-hydroxyvitamin D after several months, without the need for blood tests or medical monitoring. The amount depends on body weight and obesity status. For 70 kg 154 lb body weight, without obesity, 0.125 mg (125 micrograms = 5000 IU) is a good amount.

“5000 International Units” a day sounds like a lot, but it is a gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory.

Most doctors are not aware of the immune system’s need for 50 ng/mL or more circulating 25-hydroxyvitamin D, so they regard 20 ng/mL (50 nmol/L) or perhaps 30 ng/mL (75 nmol/L) as sufficient for good health. These levels are sufficient to supply the kidneys in their role of maintaining a very low (0.05 to 0.1 ng/mL) level of circulating calcitriol (1,25-dihydroxyvitamin D) in the bloodstream, where it functions as a hormone - a long-distance, blood-borne (also perhaps in the cerebrospinal fluid) molecule whose level (concentration) affects the behavior of one of more types of cell in distant parts of the body. This is the one hormonal function of the three molecules - to enable the kidneys to play their role in regulating calcium-phosphate-bone metabolism.

Most doctors and immunologists are not aware of 25-hydroxyvitamin D ==> calcitriol intracrine (inside an individual cell, sometimes mistakenly referred to as “autocrine”) and paracrine (to nearby cells, often of different types) signaling, since they have only been discovered in the last 20 years and since there are no peer-reviewed tutorials which explain them. These signaling systems are unrelated to hormonal signaling and are essential to many types of immune cell’s ability to respond to their changing circumstances. I wrote a non-peer-reviewed tutorial on these signaling systems in 2020: Vitamin D intracrine signaling - illustrated tutorial (Also, incorrectly, referred to as Vitamin D based autocrine signaling.). A simplified version is at: https://vitamindstopscovid.info/00-evi/#02-compounds.

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:+1: Thanks very much robin-whittle. Great info.

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Thanks HelenT and jrGerber, I take all those. Robin-whittle my vit D levels are high.

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Thanks, I take all those.

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Thanks, I do those.

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Thanks, my Vitamin D level is high.

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Hopefully more info or ideas will trickle in, in the meanwhile, if you find other articles that you think are of interest please do share

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My white blood cell counts are low as well. In my experience these measurements are very hard to modify. If you are not still not vulnerable to urinary tract infections then I would not worry about it.

Mistargeted antibodies are of course not good. My mother died from mistargeted antibodies to blood clotting factors. Ivermectin might be able to help regulate our immune system, but this would be yet another off label use, with uncertain evidence.

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I am a lay person, a carpenter/bookkeeper/builder/building designer.. I know next to nothing as to lymphocytes, but a few things I know complements of a very wise and seasoned technician who I befriended and who has experience in the lab of a large hospital in the USA.

Before I dig in -thank you to the discussions above which have references, I will be digging in, great detail- a blessing, thank you!

//I got to know this seasoned technician person during 2022 -2023 and this person would speak often of the blood work confidently in the hospital during raging of Covid. The subject was the alterations of the lymphocytes and T-cells which were severely “badly” altered with those of covid -many who passed (this was hospital with many sick- halls were filled), some did not and these ironically had not lymphocyte and T-cell issues. This person, in decades on this job task, had never seen this before.

The other correlation which was glaring to this lab technician was that there was, in a 15 to 18 month time period, never an exception to this statement: low vitamin D, and it was more than half the sick folks had whatever was bad as to lymphocytes and T-cells, many many of these folks died - they died in huge numbers (no exaggeration). When vitamin D level was robust and higher (I did not know the Vit D numbers) these folks kicked Covid & got well rapidly.

I heard this before I heard the vit D conversations on the weekly videos on FLCCC, back then.

This lab tech also said, as this lab tech was employed without getting the vaccine (very difficult journey with hospital, was only a remnant of non-vaxxed in the hospital): When the hospital’s employed nurses and docs were vaccinated they caught covid 2 to 4 times- most than in the 3 to 4 times group. This caused enormous doctor nurses shortages- they could not tend to the overflow number of sick hospital patients, understaffed, so many died ongoing. When the remnant of docs and nurses did not vaccinate they caught covid none or 1 time, on average. It was remarkable to this lab tech that many docs and nurses unvaccinated did not get sick working around everyone sick.

//Here is another issue I have experienced. My PSA at age 70+ ramped up from 4 to 6.7 a year ago in a 6 month time period. My vit D level was 36 or 38. I took the BOLO method from Dr Marik’s Cancer Care and in 30 days from the start of BOLO I increased my vit D from 38 to 85, same time my PSA went down in this 30 days to 5.2.

My research (many sources) has found that many people have low vitamin D levels below the 30 or so level, and when their levels are at 80 to 100 their immune system thrive, and the people are less sick with all their issues.

Most folk say “I take vit D or D3K2, so I am ok with my Vitamin D intake. I take it with my other vitamins” or whatever.

But that means little, I believe. I have read (true or not?) that each persons vit D level correlates to their unique DNA, and many other factors. The levels of vitamin D in a person are only revealed by bloodwork.

When my Vit D went to 85 I was more alert, did not need afternoon napping, my energy was much higher, I did not require as much sleep, I took in morning so would not interfere with sleep, I received a slight tummy ache with the BOLO ramping up with vit D pills, I found cheap Vit D pills gave tummy aches and then my pharmacy grade vit D did not (big difference), I did not get chilled with high vit D, and my mental capacity of doing bookkeeping work for a company and engineering building design work was much faster accurate & creative.

So I am a believer in awareness of vit D blood levels. As well, I am having friends with cancer now using Dr Marik’s Cancer Care book and they all ramp up the Vit D and I know that 1 had malignancy in both lungs disappear at a level of vitamin D of 120 (they did chemo) and a mass in another person wrapped around a person’s vertebrate has disappeared, no chemo. These folks expressly followed Dr Marik.

In summary, pardon my non- medical and jumping around summary. Hope there is some good gleaned from my observations.

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Hi Tommy, I assume you are writing from the United States where 25-hydroxyvitamin D levels are measured in ng/mL (billionths of a gram per millilitre). For those in the UK, New Zealand, Canada (I think) or here in Australia, multiply the ng/mL figure by 2.5 to get the value in nanomols per litre (nmol/L) as are used in these countries. A mole is a number of molecules: 6.022 X 10 to the power 23 (Avogadro’s constant).

So your “85” (ng/mL) is 212.5 nmol/L. I regard this as a perfectly healthy 25-hydroxyvitamin D level for almost everyone unless there is well-informed medical advice to the contrary - but I am an electronic technician and computer programmer, not a doctor. I know of many people with such levels, at least past their 60s, who are doing very much better than average for their age.

There is plenty of ill-informed medical advice regarding 25-hydroxyvitamin D levels, with many doctors thinking the 20 to 30 ng/mL range they aim for is sufficient for full health. Such doctors would probably consider 85 ng/mL to be an alarmingly high figure. They are not familiar with the best research

The 25-hydroxyvitamin D level varies with many factors for a given body weight and amount of vitamin D3 supplementation. Some of these would be related to genes. I think that Prof. Wimalawansa’s recommendations (Vitamin D and the Immune System - how much vitamin D3 to take, by body weight and obesity status):

70 to 90 IU / kg body weight for those not suffering from obesity (BMI < 30).

                           100 to 130 IU / kg body weight for obesity I                             & II (BMI 30 to 39).
                           
                           140 to 180 IU / kg body weight for obesity                             III (BMI > 39).

are perfectly good. The USA is the last country, as far as I know, to use pounds. Multiply pounds by 2.2 to get kilograms.

After a few months these will attain at least 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D. There is no experimental validation of these recommendations, but they are based in part on the work of some Iranian doctors in Dubai: Suggested role of Vitamin D supplementation in COVID-19 severity | Journal of Contemporary Medical Sciences.

They recommended their patients supplement 70 to 100 IU vitamin D3 per day, on average, per kilogram body weight. So the upper end of their range is slightly above Prof. Wimalawansa’s range of 70 to 90. Without supplementation, 95% of their patients had 25 hydroxyvitamin D levels below 35 ng/ml. With these body weight ratio based D3 intakes, and 7.2 mg 300,000 IU bolus initial D3 doses, all 500 or so patients over multiple years attained at least 40 ng/ml and none more than 79 ng/ml circulating 25-hydroxyvitamin D.

Those in the lower range, such as 40 to 50 or 55 ng/mL would have been the people who were suffering from obesity. The highest level was 79 ng/mL, which (I think it is reasonable to assume) would have been for one or a few patients with normal or underweight body morphology, not overweight or suffering from obesity.

We don’t know exactly how much these patients supplemented, but I think it shows that Prof. Wimalawansa’s recommendations, for people not suffering from obesity, will not generally raise levels above 60 ng/mL and will generally not above 80 ng/mL.

Your report of the technician’s observations of 25-hydroxyvitamin D levels and COVID-19 deaths strikes me as entirely accurate. Most people cannot imagine that the majority of the medical profession, and whole governments, could be so corrupted and/or clueless as to take no interest in these observations and/or deny and suppress them, because if their extraordinary, ill-placed, faith in vaccines - and in the mRNA and adenovirus vector gene therapy injections falsely portrayed as vaccines. This is what happened, and tide is only slowly turning, with a majority of medical professionals, albeit less than a few years ago, still ignoring this crucial evidence of the immune system’s need for 25-hydroxyvitamin D levels well above the 15 to 25 ng/mL which is typical of those who get little UV-B skin exposure, and who not supplement vitamin D3 properly.

Here is graph depicting such anti-correlation between 25-hydroxyvitamin D levels and COVID-19 severity. Links to the research articles from which this data is derived: https://aminotheory.com/cv19/#vc

I have also attached a depiction of similar observations from Dror et al. 2022: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0263069.

The third graph is adapted from Tuncay et al. 2021 A notable key for estimating the severity of COVID-19: 25....

Long may you walk hills! I am 69, so I am right behind you.

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Thanks for your input. My vitamin D is high, not only from supplements but from a lot of sun. I actually don’t catch things, couldn’t catch Covid even when I tried. But because of an immune deficiency I already lack antibodies to many things, especially bacterial and fungal. It may also be why the C19 shot caused my cancer. But it’s years later and my WBC continue to drop, down to 2.6 now. It seems like EBV or something similar could be a cause. I’ve had that several times before so will look into that.