Vitamin D3 (cholecalciferol) supplementation is essential for most people to attain at least the 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) level of 25-hydroxyvitamin D (calcifediol or “calcidiol” AKA “25(OH)D”) in the bloodstream, which the immune system needs in order to function properly.
This is an important exception to the general principle that we can gain all the nutrients we need from food.
The natural source of vitamin D3 is ultraviolet B exposure of our skin, but this always damages DNA and so raises the risk of skin cancer. Those with brown or black skin need very large amounts of UV-B to generate enough vitamin D3 to be hydroxylated, mainly in the liver, to the circulating 25(OH)D the immune system and the kidneys need. Far from the equator, sufficient UV-B light for even white-skinned people to attain 50 ng/mL or more 25(OH)D is only available in the middle of cloud-free summer days, without glass, clothing or sunscreen intervening.
All medical professionals know that the kidneys need about 20 ng/mL circulating 25(OH)D. Some are aware that higher levels are required for the immune system to function properly. The clearest measure of the level required is from Quraishi et al. 2014 https://jamanetwork.com/journals/jamasurgery/articlepdf/1782085/soi130062.pdf. They showed that the risk of post-operative infections dropped to only 2.5% (separately for hospital acquired infections and for surgical site infections) for levels of 50 ng/mL or more. See the first graph below. Many people have half or less than this. At 20 ng/mL, which is normal for many people in winter, the risk of each of these two types of infections was about 25%.
“Vitamin D” blood tests measure the level of 25-hydroxyvitamin D in the bloodstream. Neither vitamin D3 nor 25-hydroxyvitamin D are hormones.
There is no such thing as a vitamin D rich food. Some foods contain tiny amounts which can raise rock-bottom 25(OH)D levels somewhat, and so reduce the risk of children developing rickets. However, no practical amount of food can supply more than a small fraction of the vitamin D3 we need for full health.
Please see the research cited and discussed regarding the vitamin D compounds and the immune system, at: https:// vitamindstopscovid.info/00-evi/.
This begins with recommendations from New Jersey based Professor of Medicine, Sunil Wimalawansa on the average daily supplemental intake quantities of vitamin D3 which will attain least 50 ng/mL circulating 25-hydroxyvitamin D, over several months, without the need for blood tests or medical monitoring:
70 to 90 IU / kg body weight for those not suffering from obesity (BMI < 30).
100 to 130 IU / kg body weight for obesity I & II (BMI 30 to 39).
140 to 180 IU / kg body weight for obesity III (BMI > 39).
For 70 kg (154 lb) body weight without obesity, this is about 0.125 milligrams (125 micrograms 5000 IU) a day. This is 8 or more times what most governments recommend. “5000 IU” a day sounds like a lot, but it is a gram every 22 years - and pharma-grade vitamin D costs about USD$2.50 a gram ex-factory.
These recommendations are included in a recent article with another professor of medicine Scott T. Weiss and professor of pediatrics Bruce W. Hollis: https:// www.mdpi.com/2072-6643/16/22/3969. All three have been researching vitamin D for decades. These ranges of ratios of body weight first appeared in an FLCCC webinar with Professor Wimalawansa in August 2023: Understanding Vitamin D: FLCCC Weekly Update (Aug. 16, 2023). They are an adaptation of recommendations in his July 2020 article in Nutrients “Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19” https://www.mdpi.com/2072-6643/14/14/2997.
Prof. Wimalawansa’s vitamin D recommendations have been part of at least some FLCCC protocols since early 2022. His recommended daily average vitamin D3 supplemental intake quantities can be met with larger amounts every week to ten days, such as a 1.25 mg (50,000 IU) capsule every ten days.
These healthy intake quantities take several months to raise circulating 25(OH)D levels from typical, 10 to 25 ng/mL, unsupplemented levels. To boost circulating 25-hydroxyvitamin D in clinical emergencies, a loading (bolus = single, large) dose of 10 mg (400,000 IU) for average weight adults will raise the level safely over 50 ng/mL in several days, since it takes time for it to be hydroxylated in the liver. The best approach, as recommended by Prof. Wimalawansa in FLCCC protocols, is a single oral dose of about 1 mg of calcifediol, which is 25-hydroxyvitamin D. This is easily absorbed and goes straight into circulation in the bloodstream. This will raise the 25(OH)D level safely over 50 ng/mL in about 4 hours.
Many types of immune cell require a good supply, by diffusion from the bloodstream, of 25-hydroxyvitamin D, made primarily in the liver from ingested or UV-B → skin produced vitamin D3 cholecalciferol. The cells use this as a raw material to run their intracrine (inside each cell) and paracrine (to nearby cells, typically of different types), signaling systems. These systems are crucial to each cell’s ability to adapt its behavior to its changing circumstances.
These are unrelated to hormonal (endocrine) signaling. Since, as far as I know, there are no tutorial explanations of these, I wrote one in late 2020: Vitamin D intracrine signaling - illustrated tutorial (Also, incorrectly, referred to as Vitamin D based autocrine signaling.).
A less detailed tutorial is at the start of: Vitamin D and the Immune System - how much vitamin D3 to take, by body weight and obesity status. Every doctor, nurse, immunologist, vaccinologist, virologist etc. should understand these signaling systems.