Hi Everyone, my husband’s PSA levels have risen 6 months post radical Prostetctomy (his three months level was .02, now .06, Australia testing). We have been following the protocols and increased his IVM dosage and he gets such brain fog from the increased dosage! I’ve googled until the cows come home, but am unable to find anything to counteract the overwhelming lethary and stalled cognitive function he suffers from when the dosage is more than his weight per mg (neigh). It is affecting his job (upper management), and he does a fair bit of travel for his work as well. Now, the good news is that he can still play golf and his handicap hasn’t suffered, but it would be great to see if anyone has any ideas about how to lift the fog from the increased dosage?
From my experience, the most important component (to avoid the transient side effects) is to ensure that the updosing schedule is slow.
There is a somewhat slower effect in changes to the brain (due to the secondary blood brain barrier transition, which is far slower than general blood level titration). So many folks i’ve worked with have made the mistake of thinking they can updose rapidly.
I’ve GENERALLY seen it work best in a slow process of only updosing +12mg every 3-5 days (During the early phase where one is in the .4-.8mg/kg saturation). Then as one approaches 1mg/kg, it does better if rolled back to +12mg every 5-7 days… then every additional +12mg updose is generally delayed an additional day (so, say at 1.5mg/kg, the next updose might be at say 9 days, then the NEXT updose after that could be at 10 days, then 11 days, etc…
Yes this takes quite a bit longer, but folks who’ve I seen (who walked this out slowly) generally haven’t had the severe neuro side effects.
Thanks so much for your reply! We’ll wind it right back and work on gradual incremental changes to his dosage. 
Thanks thatechguy. Really helpful.
Thanks coelix for asking the question here. Exactly what the forum is about.
What is your husband’s homocysteine level..??.. Does he take methylated B vitamins – espeicially B12..??.. Is he on statins ..??..
Are you using a new PSA level scale? PSA level 10 is bad. Level 2 isn’t that bad. And a level less than one, at .05 or so is almost undetectable.
My prostate surgery was about 12 years ago. One time I got a score of 0.0. My scores have always been less than 1 and often undetectable. In short, from my limited understanding, and from the tests that were used for me, your scores seem to be that there is no problem.
The first one post op was .02, the second is .06. 02 or less is acceptable according to the doctor, so given the elevation of the level, there is cause to be concerned. He also said that the nine month test is probably the most important, which will be the next one. Given that my husband doesn’t have a prostate anymore, .02 or less, preferable nil detectable, is what we have been told is the goal.